Assay Detail
Functional
CHEMBL975204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.76 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | 4.0 | 1 | 8.77 |
| CHEMBL468204 | — | — | 1 | 8.31 |
| CHEMBL468862 | — | — | 1 | 8.15 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 7.57 |
| CHEMBL496100 | — | — | 1 | 7.39 |
| CHEMBL498360 | — | — | 1 | 7.26 |
| CHEMBL468768 | — | — | 1 | 7.20 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 7.19 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 7.11 |
| CHEMBL511255 | — | — | 1 | 6.88 |
| CHEMBL525188 | — | — | 1 | 6.87 |
| CHEMBL466547 | — | — | 1 | 6.01 |
| CHEMBL466326 | — | — | 1 | 6.00 |
| CHEMBL468205 | — | — | 1 | 5.99 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | 5.82 |
| CHEMBL466546 | — | — | 1 | 5.64 |
| CHEMBL467782 | — | — | 1 | 5.56 |
| CHEMBL468631 | — | — | 1 | 5.50 |
| CHEMBL495463 | — | — | 1 | 5.20 |
| CHEMBL466352 | — | — | 1 | - |
| CHEMBL468632 | — | — | 1 | - |
| CHEMBL511574 | — | — | 1 | - |
| CHEMBL498161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL468204 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL468862 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL496100 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL498360 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL468768 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL511255 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL525188 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL466547 | — | IC50 | = | 983.0 | nM | 6.01 |
| CHEMBL466326 | — | IC50 | = | 995.0 | nM | 6.00 |
| CHEMBL468205 | — | IC50 | = | 1034.0 | nM | 5.99 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 1519.0 | nM | 5.82 |
| CHEMBL466546 | — | IC50 | = | 2289.0 | nM | 5.64 |
| CHEMBL467782 | — | IC50 | = | 2778.0 | nM | 5.56 |
| CHEMBL468631 | — | IC50 | = | 3138.0 | nM | 5.50 |
| CHEMBL495463 | — | IC50 | = | 6277.0 | nM | 5.20 |
| CHEMBL466352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL468632 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL511574 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498161 | — | IC50 | > | 1000.0 | nM | - |