Assay Detail
Functional
CHEMBL975257
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Cytotoxicity against human SMMC-7541 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7541 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.70 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41177 | SQUAMOCIN | — | 1 | 10.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.43 |
| CHEMBL447802 | — | — | 1 | 8.08 |
| CHEMBL606053 | ASIMICIN | — | 1 | 7.96 |
| CHEMBL452936 | Squamocin-D | — | 1 | 7.92 |
| CHEMBL484529 | ISODESACETYLUVARICIN | — | 1 | 7.80 |
| CHEMBL447119 | Squamostatin-A | — | 1 | 7.30 |
| CHEMBL448616 | Squamostatin-D | — | 1 | 7.27 |
| CHEMBL506139 | — | — | 1 | 7.22 |
| CHEMBL503744 | DEACETYLUVARICIN | — | 1 | 6.85 |
| CHEMBL499780 | Squamostatin-B | — | 1 | 6.77 |
| CHEMBL448377 | Squamostatin-E | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL447802 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL606053 | ASIMICIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL452936 | Squamocin-D | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL484529 | ISODESACETYLUVARICIN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL447119 | Squamostatin-A | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL448616 | Squamostatin-D | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL506139 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL503744 | DEACETYLUVARICIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL499780 | Squamostatin-B | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL448377 | Squamostatin-E | IC50 | = | 180.0 | nM | 6.75 |