Assay Detail
Functional
CHEMBL975258
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Cytotoxicity against human A-5408 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-5408 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.75 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41177 | SQUAMOCIN | — | 1 | 9.06 |
| CHEMBL448616 | Squamostatin-D | — | 1 | 8.85 |
| CHEMBL452936 | Squamocin-D | — | 1 | 8.74 |
| CHEMBL447119 | Squamostatin-A | — | 1 | 8.59 |
| CHEMBL606053 | ASIMICIN | — | 1 | 8.44 |
| CHEMBL506139 | — | — | 1 | 7.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.58 |
| CHEMBL499780 | Squamostatin-B | — | 1 | 7.37 |
| CHEMBL448377 | Squamostatin-E | — | 1 | 6.89 |
| CHEMBL484529 | ISODESACETYLUVARICIN | — | 1 | 6.80 |
| CHEMBL447802 | — | — | 1 | 6.50 |
| CHEMBL503744 | DEACETYLUVARICIN | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL448616 | Squamostatin-D | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL452936 | Squamocin-D | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL447119 | Squamostatin-A | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL606053 | ASIMICIN | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL506139 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL499780 | Squamostatin-B | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL448377 | Squamostatin-E | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL484529 | ISODESACETYLUVARICIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL447802 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL503744 | DEACETYLUVARICIN | IC50 | = | 400.0 | nM | 6.40 |