Assay Detail
Functional
CHEMBL975629
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.73 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.21 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.82 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.74 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.63 |
| CHEMBL504525 | — | — | 1 | 7.54 |
| CHEMBL505269 | — | — | 1 | 7.52 |
| CHEMBL510022 | — | — | 1 | 7.38 |
| CHEMBL510273 | — | — | 1 | 7.33 |
| CHEMBL446383 | NEOTHALIBRINE | — | 1 | 7.33 |
| CHEMBL443331 | — | — | 1 | 7.32 |
| CHEMBL507220 | — | — | 1 | 7.32 |
| CHEMBL504018 | — | — | 1 | 7.21 |
| CHEMBL503522 | — | — | 1 | 7.19 |
| CHEMBL509310 | — | — | 1 | 7.14 |
| CHEMBL506363 | — | — | 1 | 7.12 |
| CHEMBL505900 | — | — | 1 | 7.10 |
| CHEMBL509803 | — | — | 1 | 7.07 |
| CHEMBL447886 | COCSULINE | — | 1 | 7.06 |
| CHEMBL443597 | — | — | 1 | 7.05 |
| CHEMBL450175 | — | — | 1 | 6.97 |
| CHEMBL502441 | — | — | 1 | 6.97 |
| CHEMBL502592 | — | — | 1 | 6.96 |
| CHEMBL487904 | — | — | 1 | 6.94 |
| CHEMBL449198 | — | — | 1 | 6.94 |
| CHEMBL508608 | — | — | 1 | 6.93 |
| CHEMBL454476 | — | — | 1 | 6.89 |
| CHEMBL504323 | BERBAMINE | — | 1 | 6.89 |
| CHEMBL492604 | — | — | 1 | 6.87 |
| CHEMBL500324 | TRILOBINE | — | 1 | 6.77 |
| CHEMBL509855 | HOMOAROMOLINE | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.18 | nM | 8.21 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 18.12 | nM | 7.74 |
| CHEMBL170 | QUININE | IC50 | = | 23.38 | nM | 7.63 |
| CHEMBL504525 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL505269 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL510022 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL510273 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL446383 | NEOTHALIBRINE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL443331 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL507220 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL504018 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL503522 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL509310 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL506363 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL505900 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL509803 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL447886 | COCSULINE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL443597 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL450175 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL502441 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL502592 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL487904 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL449198 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL508608 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL454476 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL504323 | BERBAMINE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL492604 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL500324 | TRILOBINE | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL509855 | HOMOAROMOLINE | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL504256 | FANGCHINOLINE | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL500614 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL452609 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL463946 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL507792 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL500609 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL449690 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL176045 | FANCHININ | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL445477 | PHAEANTHINE | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL506701 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL443367 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL452895 | OBAMEGINE | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL464525 | OBABERINE | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL503241 | ISOTRILOBINE | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL508781 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL446648 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL452663 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL445000 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL499945 | — | IC50 | = | 1030.0 | nM | 5.99 |