Assay Detail
Binding
CHEMBL975663
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Inhibition of human AChE by Ellman's assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.10 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470867 | TASPINE | — | 1 | 6.27 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.93 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL469423 | (-)-ASIMILOBINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470867 | TASPINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL95 | TACRINE | IC50 | - | — | - | |
| CHEMBL469423 | (-)-ASIMILOBINE | IC50 | > | 100000.0 | nM | - |