Assay Detail
Binding
CHEMBL975727
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Inhibition of rat DNA polymerase beta assessed as [3H]TTP incorporation after 60 mins by scintillation counting in presence of bovine serum albumin
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.18 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426392 | BISNORSTRIATOL | — | 1 | 5.24 |
| CHEMBL455349 | — | — | 1 | 5.19 |
| CHEMBL455348 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426392 | BISNORSTRIATOL | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL455349 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL455348 | — | IC50 | = | 7500.0 | nM | 5.12 |