Assay Detail
Functional
CHEMBL975909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 by cell-based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: introducing a diketoacid functionality into delavirdine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.52 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 7.68 |
| CHEMBL495410 | — | — | 1 | 6.28 |
| CHEMBL493409 | — | — | 1 | 6.10 |
| CHEMBL494757 | — | — | 1 | 6.01 |
| CHEMBL494758 | — | — | 1 | - |
| CHEMBL494420 | — | — | 1 | - |
| CHEMBL493220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593 | DELAVIRDINE | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL495410 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL493409 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL494757 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL494758 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL494420 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL493220 | — | EC50 | > | 10000.0 | nM | - |