Assay Detail
Binding
CHEMBL976164
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Inhibition of COX2 in mouse peritoneal macrophages
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.33 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469785 | — | — | 1 | 7.85 |
| CHEMBL504535 | IMRECOXIB | 1.0 | 1 | 7.75 |
| CHEMBL469574 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469785 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL504535 | IMRECOXIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL469574 | — | IC50 | = | 410.0 | nM | 6.39 |