Assay Detail
Functional
CHEMBL976267
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Cytostatic activity against human Molt4/C8 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.40 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL528548 | — | — | 1 | 4.68 |
| CHEMBL508468 | — | — | 1 | 4.62 |
| CHEMBL455392 | — | — | 1 | 4.44 |
| CHEMBL455416 | — | — | 1 | 4.36 |
| CHEMBL488856 | — | — | 1 | 4.35 |
| CHEMBL455151 | — | — | 1 | 4.30 |
| CHEMBL455391 | — | — | 1 | 4.28 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | — | 1 | 4.13 |
| CHEMBL455417 | — | — | 1 | - |
| CHEMBL453609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL528548 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL508468 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL455392 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL455416 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL488856 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL455151 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL455391 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL455417 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL453609 | — | IC50 | >= | 500000.0 | nM | - |