Assay Detail
Functional
CHEMBL976277
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Cytotoxicity against mouse BA/F3 cells transfected with wild-type Bcr-Abl
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.92 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454358 | — | — | 1 | 7.68 |
| CHEMBL459877 | — | — | 1 | 7.57 |
| CHEMBL509002 | — | — | 1 | 7.49 |
| CHEMBL518166 | — | — | 1 | 7.46 |
| CHEMBL516498 | — | — | 1 | 7.46 |
| CHEMBL510893 | — | — | 1 | 7.43 |
| CHEMBL517256 | — | — | 1 | 7.41 |
| CHEMBL461767 | — | — | 1 | 7.29 |
| CHEMBL509941 | — | — | 1 | 7.13 |
| CHEMBL451790 | — | — | 1 | 6.91 |
| CHEMBL528330 | — | — | 1 | 6.91 |
| CHEMBL488840 | — | — | 1 | 6.78 |
| CHEMBL454611 | — | — | 1 | 6.70 |
| CHEMBL454873 | — | — | 1 | 6.57 |
| CHEMBL461768 | — | — | 1 | 6.54 |
| CHEMBL454872 | — | — | 1 | 6.54 |
| CHEMBL452563 | — | — | 1 | 6.07 |
| CHEMBL454868 | — | — | 1 | 5.81 |
| CHEMBL510891 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454358 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL459877 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL509002 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL518166 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL516498 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL510893 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL517256 | — | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL461767 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL509941 | — | IC50 | = | 73.7 | nM | 7.13 |
| CHEMBL451790 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL528330 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL488840 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL454611 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL454873 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL461768 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL454872 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL452563 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL454868 | — | IC50 | = | 1541.0 | nM | 5.81 |
| CHEMBL510891 | — | IC50 | = | 2006.0 | nM | 5.70 |