Assay Detail
Binding
CHEMBL976443
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Inhibition of HDAC3 after 17 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.73 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511749 | — | — | 1 | 9.38 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.70 |
| CHEMBL468595 | — | — | 1 | 8.39 |
| CHEMBL467793 | — | — | 1 | 7.99 |
| CHEMBL513160 | — | — | 1 | 7.89 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.77 |
| CHEMBL468842 | — | — | 1 | 7.75 |
| CHEMBL468841 | — | — | 1 | 7.18 |
| CHEMBL469275 | — | — | 1 | 7.08 |
| CHEMBL467792 | — | — | 1 | 6.94 |
| CHEMBL446512 | — | — | 1 | 6.84 |
| CHEMBL467998 | — | — | 1 | 6.80 |
| CHEMBL469274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511749 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL468595 | — | IC50 | = | 4.04 | nM | 8.39 |
| CHEMBL467793 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL513160 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL468842 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL468841 | — | IC50 | = | 65.8 | nM | 7.18 |
| CHEMBL469275 | — | IC50 | = | 83.6 | nM | 7.08 |
| CHEMBL467792 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL446512 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL467998 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL469274 | — | IC50 | < | 0.002 | nM | - |