Assay Detail
Binding
CHEMBL976446
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Inhibition of HDAC10 after 17 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.91 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.30 |
| CHEMBL468595 | — | — | 1 | 7.76 |
| CHEMBL469274 | — | — | 1 | 7.55 |
| CHEMBL467793 | — | — | 1 | 7.35 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.14 |
| CHEMBL468842 | — | — | 1 | 7.14 |
| CHEMBL511749 | — | — | 1 | 7.04 |
| CHEMBL513160 | — | — | 1 | 6.81 |
| CHEMBL468841 | — | — | 1 | 6.40 |
| CHEMBL467792 | — | — | 1 | 6.16 |
| CHEMBL446512 | — | — | 1 | 6.08 |
| CHEMBL467998 | — | — | 1 | 6.07 |
| CHEMBL469275 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL468595 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL469274 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL467793 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL468842 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL511749 | — | IC50 | = | 90.7 | nM | 7.04 |
| CHEMBL513160 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL468841 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL467792 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL446512 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL467998 | — | IC50 | = | 852.0 | nM | 6.07 |
| CHEMBL469275 | — | IC50 | = | 891.0 | nM | 6.05 |