Assay Detail
Binding
CHEMBL976461
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Inhibition of human recombinant CA5B by CO2 hydration assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.50 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512809 | — | — | 1 | 7.98 |
| CHEMBL469220 | — | — | 1 | 7.97 |
| CHEMBL513184 | — | — | 1 | 7.97 |
| CHEMBL468367 | — | — | 1 | 7.95 |
| CHEMBL445517 | — | — | 1 | 7.94 |
| CHEMBL469064 | — | — | 1 | 7.92 |
| CHEMBL468839 | — | — | 1 | 7.89 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.52 |
| CHEMBL513185 | — | — | 1 | 7.29 |
| CHEMBL467979 | — | — | 1 | 7.28 |
| CHEMBL469221 | — | — | 1 | 7.27 |
| CHEMBL222837 | — | — | 1 | 7.25 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512809 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL469220 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL513184 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL468367 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL445517 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL469064 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL468839 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL513185 | — | Ki | = | 51.8 | nM | 7.29 |
| CHEMBL467979 | — | Ki | = | 52.3 | nM | 7.28 |
| CHEMBL469221 | — | Ki | = | 54.2 | nM | 7.27 |
| CHEMBL222837 | — | Ki | = | 55.8 | nM | 7.25 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 6033.0 | nM | 5.22 |