Assay Detail
Binding
CHEMBL976899
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Inhibition of EGFR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.40 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 7.04 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 5.59 |
| CHEMBL450786 | PHA-665752 | — | 1 | 5.42 |
| CHEMBL189584 | PD-173074 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL180022 | NERATINIB | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL189584 | PD-173074 | IC50 | > | 50000.0 | nM | - |