Assay Detail

CHEMBL977029

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Binding

Inhibition of ribosomal activity in erythromycin-resistant Propionibacterium acnes GE4E carrying Erm(X) gene assessed as luciferase production by transcriptional and translational assay

ChEMBL ↗

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Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Open DB target context

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Bacterial 70S ribosome (CHEMBL2363135) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bacterial 70S ribosome

CHEMBL2363135

Anchored from Assay target.

Protein identity Bacterial 70S ribosome

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cutibacterium acnes
Subcellular	Ribosome
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Type	PROTEIN NUCLEIC-ACID COMPLEX
Organism	Bacteria

Publication

Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes.

Dreier J, Amantea E, Kellenberger L, Page MG.
Antimicrob Agents Chemother (2007) 51 : 4361 -4365
PubMed 17923495 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.22	6.72
Inhibition	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL405863	—	—	2	6.72
CHEMBL532	ERYTHROMYCIN	4.0	2	5.72

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL405863	—	IC50	=	190.0	nM	6.72
CHEMBL532	ERYTHROMYCIN	IC50	=	1900.0	nM	5.72
CHEMBL532	ERYTHROMYCIN	Inhibition	=	52.0	%	-
CHEMBL405863	—	Inhibition	=	48.0	%	-