Assay Detail
Functional
CHEMBL977254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-3 adrenergic receptor (CHEMBL4400) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.49 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514102 | — | — | 1 | 7.60 |
| CHEMBL59765 | — | — | 1 | 7.52 |
| CHEMBL503209 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514102 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL59765 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL503209 | — | EC50 | = | 46.0 | nM | 7.34 |