Assay Detail
Binding
CHEMBL977366
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Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]alpha-methyl glucopyranoside
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.58 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447016 | — | — | 1 | 8.10 |
| CHEMBL488696 | — | — | 1 | 7.66 |
| CHEMBL245067 | PHLORIZIN | — | 1 | 7.46 |
| CHEMBL486461 | — | — | 1 | 7.16 |
| CHEMBL486670 | — | — | 1 | 6.72 |
| CHEMBL487667 | — | — | 1 | 6.54 |
| CHEMBL486637 | — | — | 1 | 6.37 |
| CHEMBL520379 | — | — | 1 | 6.32 |
| CHEMBL486664 | — | — | 1 | 6.29 |
| CHEMBL488839 | — | — | 1 | 6.27 |
| CHEMBL486837 | — | — | 1 | 6.21 |
| CHEMBL507895 | — | — | 1 | 6.20 |
| CHEMBL520894 | — | — | 1 | 6.15 |
| CHEMBL486636 | — | — | 1 | 6.01 |
| CHEMBL487650 | — | — | 1 | 5.92 |
| CHEMBL487666 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447016 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL488696 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL245067 | PHLORIZIN | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL486461 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL486670 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL487667 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL486637 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL520379 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL486664 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL488839 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL486837 | — | EC50 | = | 623.0 | nM | 6.21 |
| CHEMBL507895 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL520894 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL486636 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL487650 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL487666 | — | EC50 | = | 1200.0 | nM | 5.92 |