Compound Detail
CHEMBL520894
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OC[C@H]1O[C@@H](c2cccc(CCc3ccccc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL520894 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RBJBRHIXKVMRFX-OBKDMQGPSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
0.99
ALogP
5
HBA
4
HBD
90.2
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | EC50 | 6.15 | 6.15 | 710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 | EC50 | = | 710.0 | nM | 6.15 | Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accum... | 18707880 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18707880 | 10.1016/j.bmcl.2008.07.109 | Sodium/glucose cotransporter 2 | 1 |
Data from ChEMBL 36 via Core Engine