Assay Detail
Binding
CHEMBL977755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in Wistar rat peritoneal leukocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485981 | BUDDLEDIN A | — | 1 | 4.30 |
| CHEMBL243664 | ACACETIN | — | 1 | - |
| CHEMBL465682 | BUDDLEDIN C | — | 1 | - |
| CHEMBL519046 | BUDDLEDIN B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485981 | BUDDLEDIN A | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL243664 | ACACETIN | IC50 | = | 123200.0 | nM | - |
| CHEMBL465682 | BUDDLEDIN C | IC50 | > | 200000.0 | nM | - |
| CHEMBL519046 | BUDDLEDIN B | IC50 | > | 200000.0 | nM | - |