Assay Detail
Functional
CHEMBL978073
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Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DAN-G |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.53 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486866 | — | — | 1 | 6.70 |
| CHEMBL440896 | — | — | 1 | 6.22 |
| CHEMBL452338 | — | — | 1 | 6.21 |
| CHEMBL510628 | — | — | 1 | 6.14 |
| CHEMBL508642 | — | — | 1 | 5.82 |
| CHEMBL671 | THIOTEPA | 4.0 | 1 | 5.78 |
| CHEMBL509447 | — | — | 1 | 5.74 |
| CHEMBL451824 | — | — | 1 | 5.65 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.58 |
| CHEMBL503790 | — | — | 1 | 5.52 |
| CHEMBL452328 | — | — | 1 | 5.49 |
| CHEMBL447255 | — | — | 1 | 5.43 |
| CHEMBL454676 | — | — | 1 | 5.42 |
| CHEMBL454418 | — | — | 1 | 5.38 |
| CHEMBL455399 | — | — | 1 | 5.19 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 5.17 |
| CHEMBL505911 | — | — | 1 | 5.10 |
| CHEMBL454419 | — | — | 1 | 5.02 |
| CHEMBL507487 | — | — | 1 | 4.90 |
| CHEMBL519890 | — | — | 1 | 4.86 |
| CHEMBL486867 | — | — | 1 | 4.80 |
| CHEMBL509840 | — | — | 1 | - |
| CHEMBL455419 | — | — | 1 | - |
| CHEMBL452337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486866 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL440896 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL452338 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL510628 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL508642 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL671 | THIOTEPA | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL509447 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL451824 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL503790 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL452328 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL447255 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL454676 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL454418 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL455399 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL505911 | — | IC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL454419 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL507487 | — | IC50 | = | 12620.0 | nM | 4.90 |
| CHEMBL519890 | — | IC50 | = | 13810.0 | nM | 4.86 |
| CHEMBL486867 | — | IC50 | = | 15660.0 | nM | 4.80 |
| CHEMBL509840 | — | IC50 | - | — | - | |
| CHEMBL455419 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL452337 | — | IC50 | > | 40000.0 | nM | - |