Assay Detail
Binding
CHEMBL978248
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Inhibition of rat FAAH preincubated for 20 mins
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.79 | 8.21 |
| Ki | 1 | 8.33 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL472535 | — | — | 1 | 8.21 |
| CHEMBL461935 | — | — | 1 | 7.74 |
| CHEMBL460273 | — | — | 1 | 7.47 |
| CHEMBL461380 | — | — | 1 | 7.33 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.32 |
| CHEMBL461942 | — | — | 1 | 7.08 |
| CHEMBL518812 | — | — | 1 | 7.04 |
| CHEMBL472529 | — | — | 1 | 6.93 |
| CHEMBL472188 | — | — | 1 | 6.91 |
| CHEMBL472187 | — | — | 1 | 6.83 |
| CHEMBL518653 | — | — | 1 | 6.83 |
| CHEMBL472534 | — | — | 1 | 6.82 |
| CHEMBL461753 | — | — | 1 | 6.79 |
| CHEMBL472530 | — | — | 1 | 6.61 |
| CHEMBL516650 | — | — | 1 | 6.55 |
| CHEMBL472189 | — | — | 1 | 6.52 |
| CHEMBL461752 | — | — | 1 | 6.46 |
| CHEMBL512882 | — | — | 1 | 6.46 |
| CHEMBL461569 | — | — | 1 | 5.90 |
| CHEMBL518657 | — | — | 1 | 5.78 |
| CHEMBL470107 | — | — | 1 | 5.08 |
| CHEMBL470108 | — | — | 1 | - |
| CHEMBL471155 | — | — | 1 | - |
| CHEMBL471320 | — | — | 1 | - |
| CHEMBL471321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL472535 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL461935 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL460273 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL461380 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL184238 | URB-597 | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL461942 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL518812 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL472529 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL472188 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL472187 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL518653 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL472534 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL461753 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL472530 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL516650 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL472189 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL461752 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL512882 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL461569 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL518657 | — | IC50 | = | 1666.0 | nM | 5.78 |
| CHEMBL470107 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL470108 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL471155 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL471320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL471321 | — | IC50 | > | 10000.0 | nM | - |