Assay Detail
ADMET
CHEMBL978558
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Antiproliferative activity against human HaCaT cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.83 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493650 | — | — | 1 | 6.52 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 6.30 |
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 6.16 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.16 |
| CHEMBL493652 | — | — | 1 | 6.05 |
| CHEMBL493398 | — | — | 1 | 5.52 |
| CHEMBL294323 | — | — | 1 | 5.43 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 5.37 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 5.00 |
| CHEMBL15193 | LAPACHOL | — | 1 | - |
| CHEMBL473876 | — | — | 1 | - |
| CHEMBL1364621 | — | — | 1 | - |
| CHEMBL272253 | DEHYDRO-ALPHA-LAPACHONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493650 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL493652 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL493398 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL294323 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL15193 | LAPACHOL | IC50 | > | 10000.0 | nM | - |
| CHEMBL473876 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1364621 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272253 | DEHYDRO-ALPHA-LAPACHONE | IC50 | > | 10000.0 | nM | - |