Assay Detail
Binding
CHEMBL978650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of chicken cSrc single mutant expressed in Escherichia coli
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.07 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94061 | — | — | 1 | 6.63 |
| CHEMBL285063 | — | — | 1 | 6.47 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.00 |
| CHEMBL188762 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94061 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL285063 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL188762 | — | IC50 | = | 6400.0 | nM | 5.19 |