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Assay Detail

CHEMBL978704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at human ERalpha expressed in african green monkey CV1 cells assessed as inhibition of estrogen like activity after 24 hrs by luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CV-1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor (CHEMBL206)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bioactive compounds from Peperomia pellucida.
Xu S, Li N, Ning MM, Zhou CH, Yang QR, Wang MW.
J Nat Prod (2006) 69 : 247 -250
PubMed 16499324 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.34 9.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81 RALOXIFENE 4.0 1 9.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81 RALOXIFENE IC50 = 0.46 nM 9.34