Assay Detail
Functional
CHEMBL978903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV infected in human CEM-SS cells assessed as inhibition of virus induced cell killing by XTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Synthesis of potent antitumor and antiviral benzofuran derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280527 | ATEVIRDINE MESYLATE | 2.0 | 1 | 9.00 |
| CHEMBL3143911 | — | — | 1 | 6.00 |
| CHEMBL449897 | — | — | 1 | 6.00 |
| CHEMBL468539 | — | — | 1 | 5.70 |
| CHEMBL466907 | — | — | 1 | 5.70 |
| CHEMBL466908 | — | — | 1 | 5.52 |
| CHEMBL511905 | — | — | 1 | 5.40 |
| CHEMBL466114 | — | — | 1 | 5.40 |
| CHEMBL513819 | — | — | 1 | 5.22 |
| CHEMBL466909 | — | — | 1 | 5.05 |
| CHEMBL468747 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280527 | ATEVIRDINE MESYLATE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3143911 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL449897 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL468539 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL466907 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL466908 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL511905 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL466114 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL513819 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL466909 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL468747 | — | EC50 | = | 35000.0 | nM | 4.46 |