Assay Detail
Binding
CHEMBL979110
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Inhibition of Spirulina platensis adenylyl cyclase assessed as cAMP level by cAMP immunogenic assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Arthrospira platensis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based development of novel adenylyl cyclase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.46 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401844 | — | — | 1 | 5.30 |
| CHEMBL387152 | — | — | 1 | 4.82 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 1 | 4.16 |
| CHEMBL481854 | MADECASSIC ACID | — | 1 | 4.00 |
| CHEMBL469203 | — | — | 1 | 4.00 |
| CHEMBL512832 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401844 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL387152 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL481854 | MADECASSIC ACID | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL469203 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL512832 | — | IC50 | = | 200000.0 | nM | - |