Assay Detail
Binding
CHEMBL979122
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Inhibition of human NTPDase 2 expressed in HEK293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 2 (CHEMBL5049) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.59 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469212 | — | — | 1 | 5.09 |
| CHEMBL469243 | — | — | 1 | 4.54 |
| CHEMBL468354 | — | — | 1 | 4.14 |
| CHEMBL464548 | — | — | 1 | - |
| CHEMBL469067 | — | — | 1 | - |
| CHEMBL463519 | — | — | 1 | - |
| CHEMBL511933 | — | — | 1 | - |
| CHEMBL469244 | — | — | 1 | - |
| CHEMBL517017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469212 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL469243 | — | Ki | = | 29200.0 | nM | 4.54 |
| CHEMBL468354 | — | Ki | = | 71700.0 | nM | 4.14 |
| CHEMBL464548 | — | Ki | = | 213000.0 | nM | - |
| CHEMBL469067 | — | Ki | = | 167000.0 | nM | - |
| CHEMBL463519 | — | Ki | = | 210000.0 | nM | - |
| CHEMBL511933 | — | Ki | = | 173000.0 | nM | - |
| CHEMBL469244 | — | Ki | = | 116000.0 | nM | - |
| CHEMBL517017 | — | Ki | = | 1440000.0 | nM | - |