Assay Detail
Functional
CHEMBL979247
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Cytotoxicity against human MCF7 after 3 days by SRB assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.48 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 2 | 7.80 |
| CHEMBL282984 | — | — | 1 | 7.21 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.14 |
| CHEMBL1081 | 3-DESMETHYLCOLCHICIN | — | 1 | 6.75 |
| CHEMBL498122 | — | — | 1 | 6.70 |
| CHEMBL312862 | DEMECOLCINE | 2.0 | 1 | 6.22 |
| CHEMBL498123 | — | — | 1 | 6.10 |
| CHEMBL527025 | — | — | 1 | 5.82 |
| CHEMBL462714 | DEMECOLCINONE | — | 1 | 4.54 |
| CHEMBL516513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL282984 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL65 | CAMPTOTHECIN | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1081 | 3-DESMETHYLCOLCHICIN | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL498122 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL312862 | DEMECOLCINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL498123 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL527025 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL462714 | DEMECOLCINONE | EC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL516513 | — | EC50 | = | 130100.0 | nM | - |
| CHEMBL107 | COLCHICINE | EC50 | - | — | - |