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Assay Detail

CHEMBL979249

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SF-268 after 3 days by SRB assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SF-268
Confidence 1 — Organism
Curated By Autocuration

Target

SF-268 (CHEMBL613977)
Type CELL-LINE
Organism Homo sapiens

Publication

New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess JP, Nakanishi Y, Kroll DJ, Navarro HA, Falkinham JO, Wani MC, Oberlies NH.
J Nat Prod (2005) 68 : 173 -178
PubMed 15730238 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.97 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107 COLCHICINE 4.0 2 7.60
CHEMBL65 CAMPTOTHECIN -1.0 1 7.23
CHEMBL282984 1 7.01
CHEMBL1081 3-DESMETHYLCOLCHICIN 1 6.55
CHEMBL498122 1 6.43
CHEMBL527025 1 5.50
CHEMBL498123 1 5.50
CHEMBL312862 DEMECOLCINE 2.0 1 5.21
CHEMBL462714 DEMECOLCINONE 1 4.55
CHEMBL516513 1 4.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107 COLCHICINE EC50 = 25.0 nM 7.60
CHEMBL65 CAMPTOTHECIN EC50 = 59.0 nM 7.23
CHEMBL282984 EC50 = 97.0 nM 7.01
CHEMBL1081 3-DESMETHYLCOLCHICIN EC50 = 280.0 nM 6.55
CHEMBL498122 EC50 = 370.0 nM 6.43
CHEMBL527025 EC50 = 3200.0 nM 5.50
CHEMBL498123 EC50 = 3200.0 nM 5.50
CHEMBL312862 DEMECOLCINE EC50 = 6200.0 nM 5.21
CHEMBL462714 DEMECOLCINONE EC50 = 28400.0 nM 4.55
CHEMBL516513 EC50 = 80200.0 nM 4.10
CHEMBL107 COLCHICINE EC50 - -