Assay Detail
Binding
CHEMBL979539
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Binding affinity to adrenergic alpha1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.54 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.49 |
| CHEMBL90588 | — | — | 1 | 9.49 |
| CHEMBL25554 | — | — | 1 | 9.27 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.00 |
| CHEMBL514848 | — | — | 1 | 8.85 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.85 |
| CHEMBL92380 | — | — | 1 | 6.85 |
| CHEMBL454149 | — | — | 1 | 6.51 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL90588 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL25554 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL514848 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL42 | CLOZAPINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL92380 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL454149 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL10085 | MAZAPERTINE | Ki | < | 4.0 | nM | - |