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Compound Detail

CHEMBL514848

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Nc1nc(-c2ccc(F)cc2)c([C@@H]2CCN(CCCC(=O)c3ccc(F)cc3)C2)s1

Basic Information

ChEMBL ID CHEMBL514848
Phase Preclinical
Structure Type MOL
InChI Key PMIAIKWRXUGRQG-QGZVFWFLSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

427.5
MW (Da)
5.12
ALogP
5
HBA
1
HBD
59.2
PSA (Ų)
0.53
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H23F2N3OS
MW 427.52
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.28

Activity Summary

Ki 5 meas. best 9.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 9.27 8.9067 0.5 3
D(4) dopamine receptor
CHEMBL219
Ki 9.26 9.26 0.6 1
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 8.72 8.72 1.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18378462 10.1016/j.bmc.2008.02.091 Unchecked 3
18378462 10.1016/j.bmc.2008.02.091 D(4) dopamine receptor 1
18378462 10.1016/j.bmc.2008.02.091 5-hydroxytryptamine receptor 2A 1

Data from ChEMBL 36 via Core Engine