Assay Detail
Binding
CHEMBL980608
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Inhibition of rat lens aldose reductase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.65 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.16 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 6.80 |
| CHEMBL254213 | — | — | 1 | 5.89 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.88 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.81 |
| CHEMBL233930 | ASTRAGALIN | — | 1 | 5.29 |
| CHEMBL28 | APIGENIN | — | 1 | 5.18 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.14 |
| CHEMBL464868 | — | — | 1 | 5.04 |
| CHEMBL465526 | ERIGEROFLAVANONE | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL82242 | QUERCITRIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL254213 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL233930 | ASTRAGALIN | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL28 | APIGENIN | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL50 | QUERCETIN | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL464868 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL465526 | ERIGEROFLAVANONE | IC50 | = | 46900.0 | nM | 4.33 |