Assay Detail
Binding
CHEMBL980886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of cathepsin K inhibitors on bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249965 | — | — | 1 | 7.92 |
| CHEMBL400491 | — | — | 1 | 7.57 |
| CHEMBL249966 | — | — | 1 | 7.52 |
| CHEMBL452826 | — | — | 1 | 7.36 |
| CHEMBL527883 | — | — | 1 | 7.12 |
| CHEMBL400395 | — | — | 1 | 7.11 |
| CHEMBL528104 | — | — | 1 | - |
| CHEMBL488859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249965 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL400491 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL249966 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL452826 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL527883 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL400395 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL528104 | — | IC50 | - | — | - | |
| CHEMBL488859 | — | IC50 | - | — | - |