Assay Detail
Functional
CHEMBL980949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.14 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487635 | — | — | 1 | 7.72 |
| CHEMBL486840 | — | — | 1 | 7.62 |
| CHEMBL488018 | — | — | 1 | 7.60 |
| CHEMBL487835 | — | — | 1 | 7.51 |
| CHEMBL488857 | — | — | 1 | 7.37 |
| CHEMBL486656 | — | — | 1 | 7.21 |
| CHEMBL488690 | — | — | 1 | 7.04 |
| CHEMBL487836 | — | — | 1 | 7.01 |
| CHEMBL488855 | — | — | 1 | 6.89 |
| CHEMBL488691 | — | — | 1 | 6.82 |
| CHEMBL488704 | — | — | 1 | 6.66 |
| CHEMBL487665 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487635 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL486840 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL488018 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL487835 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL488857 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL486656 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL488690 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL487836 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL488855 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL488691 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL488704 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL487665 | — | IC50 | = | 550.0 | nM | 6.26 |