Assay Detail
Functional
CHEMBL980950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.72 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488018 | — | — | 1 | 7.16 |
| CHEMBL486840 | — | — | 1 | 6.96 |
| CHEMBL487635 | — | — | 1 | 6.70 |
| CHEMBL488857 | — | — | 1 | 6.55 |
| CHEMBL487835 | — | — | 1 | 6.50 |
| CHEMBL486656 | — | — | 1 | 6.44 |
| CHEMBL488855 | — | — | 1 | - |
| CHEMBL488691 | — | — | 1 | - |
| CHEMBL487665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488018 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL486840 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL487635 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL488857 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL487835 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL486656 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL488855 | — | IC50 | - | — | - | |
| CHEMBL488691 | — | IC50 | - | — | - | |
| CHEMBL487665 | — | IC50 | - | — | - |