Assay Detail
Binding
CHEMBL980962
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Inhibition of WNV recombinant NS2B-NS3 protease
42
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.53 | 7.50 |
| Ki | 21 | 7.28 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506092 | — | — | 2 | 8.22 |
| CHEMBL522355 | — | — | 2 | 8.05 |
| CHEMBL492866 | — | — | 2 | 7.96 |
| CHEMBL459944 | — | — | 2 | 7.89 |
| CHEMBL522831 | — | — | 2 | 7.72 |
| CHEMBL503904 | — | — | 2 | 7.70 |
| CHEMBL492867 | — | — | 2 | 7.58 |
| CHEMBL494923 | — | — | 2 | 7.55 |
| CHEMBL523197 | — | — | 2 | 7.40 |
| CHEMBL521985 | — | — | 2 | 7.39 |
| CHEMBL467624 | — | — | 2 | 7.36 |
| CHEMBL460359 | — | — | 2 | 7.34 |
| CHEMBL494301 | — | — | 2 | 7.31 |
| CHEMBL468674 | — | — | 2 | 7.28 |
| CHEMBL468049 | — | — | 2 | 7.24 |
| CHEMBL522523 | — | — | 2 | 7.09 |
| CHEMBL494699 | — | — | 2 | 6.98 |
| CHEMBL511741 | — | — | 2 | 6.96 |
| CHEMBL494922 | — | — | 2 | 6.80 |
| CHEMBL468253 | — | — | 2 | 5.68 |
| CHEMBL468885 | — | — | 2 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506092 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL522355 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL492866 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL459944 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL522831 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL503904 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL492867 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL494923 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL506092 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL523197 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL521985 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL467624 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL460359 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL494301 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL522355 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL468674 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL468049 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL492866 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL459944 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL522523 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL494699 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL522831 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL511741 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL503904 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL492867 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL494923 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL494922 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL523197 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL521985 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL460359 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL467624 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL494301 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL468674 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL468049 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL522523 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL494699 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL511741 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL494922 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL468253 | — | Ki | = | 2073.0 | nM | 5.68 |
| CHEMBL468885 | — | Ki | = | 4604.0 | nM | 5.34 |
| CHEMBL468253 | — | IC50 | = | 11565.0 | nM | 4.94 |
| CHEMBL468885 | — | IC50 | = | 25684.0 | nM | 4.59 |