Assay Detail
Functional
CHEMBL981023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 assessed as inhibition of viral replication
15
Total Activities
15
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC95 | 6 | - | - |
| ID50 | 6 | - | - |
| IC50 | 3 | 8.54 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178593 | — | — | 1 | 8.85 |
| CHEMBL461482 | — | — | 1 | 8.39 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.39 |
| CHEMBL451129 | — | — | 1 | - |
| CHEMBL18389 | — | — | 1 | - |
| CHEMBL319408 | — | — | 1 | - |
| CHEMBL101560 | — | — | 1 | - |
| CHEMBL482842 | — | — | 1 | - |
| CHEMBL486891 | — | — | 1 | - |
| CHEMBL273317 | — | — | 1 | - |
| CHEMBL161005 | — | — | 1 | - |
| CHEMBL474881 | — | — | 1 | - |
| CHEMBL315403 | — | — | 1 | - |
| CHEMBL499476 | — | — | 1 | - |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178593 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL461482 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL451129 | — | IC95 | = | 8.0 | nM | - |
| CHEMBL18389 | — | IC95 | = | 800.0 | nM | - |
| CHEMBL319408 | — | IC95 | = | 3.0 | nM | - |
| CHEMBL101560 | — | IC95 | = | 400.0 | nM | - |
| CHEMBL482842 | — | ID50 | = | 17.0 | nM | - |
| CHEMBL486891 | — | ID50 | = | 1.2 | uM | - |
| CHEMBL273317 | — | IC95 | = | 350.0 | nM | - |
| CHEMBL161005 | — | ID50 | = | 19.0 | nM | - |
| CHEMBL474881 | — | ID50 | = | 265.0 | nM | - |
| CHEMBL315403 | — | IC95 | = | 46.0 | nM | - |
| CHEMBL499476 | — | ID50 | = | 4.5 | nM | - |
| CHEMBL114 | SAQUINAVIR | ID50 | = | 18.0 | nM | - |