Assay Detail
Functional
CHEMBL981024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against protease inhibitor resistant HIV1 isolates
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.91 | 9.30 |
| IC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 9.30 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1323 | DARUNAVIR | IC90 | = | 9.0 | nM | - |