Assay Detail
Functional
CHEMBL981032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild-type HIV1 pNL4-3 infected in human MT4 cells after 5 days by MTT assay in presence of 50% human serum
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 7.44 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446273 | — | — | 1 | 8.00 |
| CHEMBL507731 | — | — | 1 | 7.92 |
| CHEMBL445225 | — | — | 1 | 7.89 |
| CHEMBL450664 | — | — | 1 | 7.82 |
| CHEMBL500344 | — | — | 1 | 7.82 |
| CHEMBL469711 | — | — | 1 | 7.82 |
| CHEMBL500895 | — | — | 1 | 7.77 |
| CHEMBL452169 | — | — | 1 | 7.75 |
| CHEMBL501017 | — | — | 1 | 7.72 |
| CHEMBL501517 | — | — | 1 | 7.72 |
| CHEMBL470508 | — | — | 1 | 7.72 |
| CHEMBL450658 | — | — | 1 | 7.70 |
| CHEMBL500987 | — | — | 1 | 7.68 |
| CHEMBL454164 | — | — | 1 | 7.60 |
| CHEMBL447675 | — | — | 1 | 7.58 |
| CHEMBL443621 | — | — | 1 | 7.57 |
| CHEMBL499841 | — | — | 1 | 7.55 |
| CHEMBL506058 | — | — | 1 | 7.52 |
| CHEMBL468355 | — | — | 1 | 7.52 |
| CHEMBL505212 | — | — | 1 | 7.52 |
| CHEMBL509152 | — | — | 1 | 7.48 |
| CHEMBL500293 | — | — | 1 | 7.48 |
| CHEMBL501764 | — | — | 1 | 7.47 |
| CHEMBL498981 | — | — | 1 | 7.44 |
| CHEMBL507451 | — | — | 1 | 7.37 |
| CHEMBL505451 | — | — | 1 | 7.28 |
| CHEMBL504219 | — | — | 1 | 7.21 |
| CHEMBL449728 | — | — | 1 | 7.20 |
| CHEMBL448299 | — | — | 1 | 7.19 |
| CHEMBL504474 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446273 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL507731 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL445225 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL450664 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL500344 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL469711 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL500895 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL452169 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL470508 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL501517 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL501017 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL450658 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL500987 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL454164 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL447675 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL443621 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL499841 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL505212 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL468355 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL506058 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL509152 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL500293 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL501764 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL498981 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL507451 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL505451 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL504219 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL449728 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL448299 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL504474 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL478332 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL503656 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL448338 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL443630 | — | EC50 | = | 311.0 | nM | 6.51 |
| CHEMBL450564 | — | EC50 | = | 346.0 | nM | 6.46 |