Assay Detail
Binding
CHEMBL981143
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Inhibition of PTP1B
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.24 | 6.09 |
| Ki | 1 | 7.66 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324968 | — | — | 1 | 7.66 |
| CHEMBL214378 | — | — | 1 | 6.09 |
| CHEMBL515797 | — | — | 1 | 5.70 |
| CHEMBL338073 | — | — | 1 | 4.89 |
| CHEMBL89067 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324968 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL214378 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL515797 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL338073 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL89067 | — | IC50 | = | 55400.0 | nM | 4.26 |