Assay Detail
Binding
CHEMBL981144
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Inhibition of LAR
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein phosphatase F (CHEMBL3521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.57 | 4.74 |
| Ki | 1 | 5.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324968 | — | — | 1 | 5.89 |
| CHEMBL89067 | — | — | 1 | 4.74 |
| CHEMBL235595 | — | — | 1 | 4.57 |
| CHEMBL338073 | — | — | 1 | 4.39 |
| CHEMBL515797 | — | — | 1 | - |
| CHEMBL214378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324968 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL89067 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL235595 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL338073 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL515797 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL214378 | — | IC50 | = | 320000.0 | nM | - |