Assay Detail
Binding
CHEMBL981145
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Inhibition of human recombinant LAR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase F (CHEMBL3521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.46 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506661 | ILLUDALIC ACID | — | 1 | 5.89 |
| CHEMBL518277 | — | — | 1 | 5.82 |
| CHEMBL454811 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506661 | ILLUDALIC ACID | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL518277 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL454811 | — | IC50 | = | 21850.0 | nM | 4.66 |