Assay Detail
Binding
CHEMBL981158
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Inhibition of human IMP dehydrogenase 2
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.63 | 8.00 |
| IC50 | 1 | 4.73 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 8.00 |
| CHEMBL392204 | — | — | 1 | 7.40 |
| CHEMBL410745 | — | — | 1 | 6.96 |
| CHEMBL446927 | — | — | 1 | 6.77 |
| CHEMBL389392 | — | — | 1 | 6.75 |
| CHEMBL410744 | — | — | 1 | 6.60 |
| CHEMBL510826 | — | — | 1 | 6.51 |
| CHEMBL444916 | — | — | 1 | 6.36 |
| CHEMBL504308 | — | — | 1 | 5.52 |
| CHEMBL476562 | MYCOPHENOLIC BIS(SULFONAMIDE) | — | 1 | 5.40 |
| CHEMBL508103 | — | — | 1 | 4.73 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | - |
| CHEMBL476563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL392204 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL410745 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL446927 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL389392 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL410744 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL510826 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL444916 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL504308 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL476562 | MYCOPHENOLIC BIS(SULFONAMIDE) | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL508103 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL477 | ADENOSINE | Ki | > | 100000.0 | nM | - |
| CHEMBL476563 | — | Ki | > | 100000.0 | nM | - |