Assay Detail
Functional
CHEMBL981179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Suppression of IL2 production in human whole blood after 24 hrs by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.00 |
| CHEMBL475609 | — | — | 1 | 6.36 |
| CHEMBL475575 | — | — | 1 | 6.32 |
| CHEMBL478642 | — | — | 1 | 5.70 |
| CHEMBL472840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL475609 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL475575 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL478642 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL472840 | — | IC50 | - | — | - |