Assay Detail
Binding
CHEMBL981259
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Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 4.99 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507312 | — | — | 1 | 6.16 |
| CHEMBL482735 | — | — | 1 | 6.10 |
| CHEMBL484332 | — | — | 1 | 6.05 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 6.00 |
| CHEMBL483354 | — | — | 1 | 5.96 |
| CHEMBL514660 | — | — | 1 | 5.85 |
| CHEMBL482734 | — | — | 1 | 5.82 |
| CHEMBL514803 | — | — | 1 | 5.82 |
| CHEMBL447259 | — | — | 1 | 5.80 |
| CHEMBL510249 | — | — | 1 | 5.75 |
| CHEMBL519477 | — | — | 1 | 5.70 |
| CHEMBL475305 | — | — | 1 | 5.48 |
| CHEMBL520490 | — | — | 1 | 5.35 |
| CHEMBL482561 | — | — | 1 | 5.30 |
| CHEMBL519503 | — | — | 1 | 5.30 |
| CHEMBL483556 | — | — | 1 | 5.26 |
| CHEMBL483849 | — | — | 1 | 4.92 |
| CHEMBL519692 | — | — | 1 | 4.89 |
| CHEMBL483999 | — | — | 1 | 4.64 |
| CHEMBL484331 | — | — | 1 | 4.55 |
| CHEMBL519845 | — | — | 1 | 4.46 |
| CHEMBL482992 | — | — | 1 | 4.40 |
| CHEMBL485361 | — | — | 1 | 4.32 |
| CHEMBL515436 | — | — | 1 | 4.30 |
| CHEMBL515243 | — | — | 1 | 4.30 |
| CHEMBL475304 | — | — | 1 | 4.16 |
| CHEMBL484136 | — | — | 1 | 4.04 |
| CHEMBL483163 | — | — | 1 | 4.00 |
| CHEMBL519323 | — | — | 1 | 4.00 |
| CHEMBL521165 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507312 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL482735 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL484332 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL483354 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL514660 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL482734 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL514803 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL447259 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL510249 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL519477 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL475305 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL520490 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL519503 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL482561 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL483556 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL483849 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL519692 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL483999 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL484331 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL519845 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL482992 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL485361 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL515436 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL515243 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL475304 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL484136 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL483163 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL519323 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL521165 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL520009 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL519996 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL484782 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL520307 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL483356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL484774 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL485009 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL521504 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL448582 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL482991 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL520175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL484923 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL520176 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL519641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483555 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL520998 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL520489 | — | IC50 | = | 250000.0 | nM | - |