Assay Detail
Binding
CHEMBL981264
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Inhibition of rat liver FBPase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482735 | — | — | 1 | 5.90 |
| CHEMBL483354 | — | — | 1 | 5.40 |
| CHEMBL482734 | — | — | 1 | 5.16 |
| CHEMBL514660 | — | — | 1 | 4.70 |
| CHEMBL519503 | — | — | 1 | 4.40 |
| CHEMBL519477 | — | — | 1 | - |
| CHEMBL507312 | — | — | 1 | - |
| CHEMBL520490 | — | — | 1 | - |
| CHEMBL484332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482735 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL483354 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL482734 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL514660 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL519503 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL519477 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL507312 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL520490 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL484332 | — | IC50 | > | 2000.0 | nM | - |