Assay Detail
Binding
CHEMBL981407
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Inhibition of Flt3
5
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of aurora kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.86 | 8.52 |
| Ki | 1 | 7.52 | 7.52 |
| Kd | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482968 | ENMD-2076 | 2.0 | 1 | 8.52 |
| CHEMBL415049 | BARASERTIB | 3.0 | 1 | 8.10 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.00 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.52 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482968 | ENMD-2076 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL415049 | BARASERTIB | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL495727 | AT-9283 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL482967 | CYC-116 | IC50 | = | 88.0 | nM | 7.06 |