Assay Detail
Binding
CHEMBL981431
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Inhibition of aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of aurora kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.03 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | 7.77 |
| CHEMBL214849 | — | — | 1 | 7.75 |
| CHEMBL214848 | — | — | 1 | 7.35 |
| CHEMBL215275 | — | — | 1 | 6.57 |
| CHEMBL217804 | — | — | 1 | 6.54 |
| CHEMBL216769 | — | — | 1 | 6.17 |
| CHEMBL216053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL214849 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL214848 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL215275 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL217804 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL216769 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL216053 | — | IC50 | < | 1.0 | nM | - |