Assay Detail
Binding
CHEMBL981501
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Inhibition of human factor 10a
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.34 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516922 | — | — | 1 | 8.74 |
| CHEMBL473243 | — | — | 1 | 8.66 |
| CHEMBL508906 | — | — | 1 | 8.64 |
| CHEMBL479863 | — | — | 1 | 8.64 |
| CHEMBL474459 | — | — | 1 | 8.60 |
| CHEMBL515569 | — | — | 1 | 8.59 |
| CHEMBL515895 | — | — | 1 | 8.54 |
| CHEMBL516195 | — | — | 1 | 8.47 |
| CHEMBL480637 | — | — | 1 | 8.46 |
| CHEMBL514798 | — | — | 1 | 8.46 |
| CHEMBL479661 | — | — | 1 | 8.38 |
| CHEMBL473856 | — | — | 1 | 8.35 |
| CHEMBL479662 | — | — | 1 | 8.27 |
| CHEMBL538657 | — | — | 1 | 8.12 |
| CHEMBL479860 | — | — | 1 | 7.92 |
| CHEMBL245678 | — | — | 1 | 7.80 |
| CHEMBL19902 | DX-9065A | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516922 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL473243 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL508906 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL479863 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL474459 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL515569 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL515895 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL516195 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL480637 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL514798 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL479661 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL473856 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL479662 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL538657 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL479860 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL245678 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL19902 | DX-9065A | IC50 | = | 70.0 | nM | 7.16 |