Assay Detail
Functional
CHEMBL981733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 8.00 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 9.01 |
| CHEMBL272584 | — | — | 1 | 8.96 |
| CHEMBL492006 | — | — | 1 | 8.72 |
| CHEMBL523265 | — | — | 1 | 8.47 |
| CHEMBL491645 | — | — | 1 | 8.34 |
| CHEMBL519985 | — | — | 1 | 8.19 |
| CHEMBL482627 | — | — | 1 | 8.18 |
| CHEMBL271576 | — | — | 1 | 8.17 |
| CHEMBL489200 | — | — | 1 | 8.14 |
| CHEMBL490222 | — | — | 1 | 8.07 |
| CHEMBL521611 | — | — | 1 | 8.03 |
| CHEMBL484265 | — | — | 1 | 8.02 |
| CHEMBL489199 | — | — | 1 | 7.96 |
| CHEMBL492005 | — | — | 1 | 7.92 |
| CHEMBL489201 | — | — | 1 | 7.89 |
| CHEMBL523817 | — | — | 1 | 7.85 |
| CHEMBL524145 | — | — | 1 | 7.68 |
| CHEMBL522641 | — | — | 1 | 7.51 |
| CHEMBL409828 | — | — | 1 | 7.41 |
| CHEMBL490415 | — | — | 1 | 7.25 |
| CHEMBL491634 | — | — | 1 | 7.22 |
| CHEMBL411234 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.97 | nM | 9.01 |
| CHEMBL272584 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL492006 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL523265 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL491645 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL519985 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL482627 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL271576 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL489200 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL490222 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL521611 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL484265 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL489199 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL492005 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL489201 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL523817 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL524145 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL522641 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL409828 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL490415 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL491634 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL411234 | — | EC50 | = | 100.0 | nM | 7.00 |